November 7, 2017
Number / % of Shares
Issued Shares624,139,184
Shares not in Public Hands2,688,366
% Shares not in Public Hands0.42%
Deferred Shares418,379,981
Share Options89,852,945
Total Fully Diluted Shares737,028,886

1. In March 2017, the Company's existing Ordinary Shares were subdivided into one new Ordinary Share of 0.05p and one Deferred Share of 0.95p. The Deferred Shares do not carry any rights. See the Company's Articles of Association as amended in March 2017, for further details.
2. The Company has no Treasury Shares in issue.
3. The total Fully Diluted Shares are calculated as Issued Shares plus Share Options and Warrants.

Significant Shareholder% of Issued Capital
Chase Nominees Limited (ELUCIT)9.77%
Barclays Direct Investing Nominees Limited (Client 1) 9.27%
Hargreaves Lansdown (Nominees) Limited (HLNOM)7.04%
TD Direct Investing Nominees (Europe) Limited (SMKTNOMS)6.39%
Hargreaves Lansdown (Nominees) Limited 6.11%
HSDL Nominees Limited5.15%
Hargreaves Lansdown (Nominees) Limited (VRA)5.08%
HSDL Nominees Limited (MAXI)4.19%
Total Significant Holders52.99%